https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42668 Wed 31 Aug 2022 16:18:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46554 Wed 29 Mar 2023 11:55:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43671 Wed 28 Sep 2022 14:55:48 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43733 Wed 28 Sep 2022 10:43:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50571 Wed 28 Feb 2024 15:53:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45150 Wed 26 Oct 2022 19:29:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45063 p< 0.01) reduced the risk of dying, after adjusting for potential confounders. While, not counting on someone to trust (HR= 1.59; p< 0.03) and having a sense a lack of control over important decisions in life increased the mortality risk. Conclusions: Given that frailty and the SDH affect health using independent pathways, public health systems in Mexico could benefit from increasing the capacity of identifying frail and isolated older adults and providing a risk-stratified health care accordingly.]]> Wed 26 Oct 2022 11:43:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46434 Wed 23 Nov 2022 13:14:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48600 Wed 22 Mar 2023 08:53:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24951 Wed 17 Nov 2021 16:32:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36096 Helicobacter pylori pathologies, cancer, coeliac disease, and autoimmune gastritis. Recent research is unraveling pathophysiology beyond symptom-only definitions, focusing on the duodenum with innate immune disturbance (duodenal eosinophilia) and microbial disruption as possible cause. Management of functional dyspepsia includes making a secure diagnosis, treatment with first-line proton pump inhibitors (PPI), then tricyclic antidepressants, and careful choice of prokinetics. Herbal treatments (peppermint oil) and STW-5 have in this age group limited efficacy. Summary: Further studies are needed to define the prevalence of functional dyspepsia in the elderly and of prime importance, to exclude organic disease as a cause for symptoms of dyspepsia.]]> Wed 15 Dec 2021 16:10:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49912 Wed 14 Jun 2023 16:05:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51664 Wed 13 Sep 2023 10:07:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53187 Wed 13 Mar 2024 08:48:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27834 Wed 11 Apr 2018 18:16:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19553 Wed 11 Apr 2018 15:55:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30241 Wed 11 Apr 2018 14:56:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30965 Wed 11 Apr 2018 13:07:37 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16008 Wed 11 Apr 2018 13:03:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21949 Wed 11 Apr 2018 13:00:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16809 Wed 11 Apr 2018 12:20:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20239 2; age, 68.8 ± 6.4 year) not meeting Australian physical activity guidelines (150 min/week of moderate to vigorous activity) were randomized to consume capsules containing 21 mg of lutein or placebo with 250 mL of full-cream milk per day for 4 weeks and encouraged to increase physical activity. Physical activity was assessed by self-report, pedometry and accelerometry (daily activity counts and sedentary time). Exercise self-efficacy was assessed by questionnaire. Thirty-nine participants competed the study (Lutein = 19, Placebo = 20). Lutein increased plasma lutein concentrations compared with placebo (p < 0.001). Absolute and percentage changes in plasma lutein were inversely associated with absolute (r = −0.36, p = 0.03) and percentage changes (r = −0.39, p = 0.02) in sedentary time. Percentage change in plasma lutein was positively associated with the percentage change in average daily activity counts (r = 0.36, p = 0.03). Exercise self-efficacy did not change (p = 0.16). Lutein increased plasma lutein, which was associated with increased physical activity and reduced sedentary time in older adults. Larger trials should evaluate whether Lutein can provide health benefits over the longer term.]]> Wed 11 Apr 2018 11:57:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13985 Wed 11 Apr 2018 10:22:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15216 Wed 11 Apr 2018 09:45:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14094 Wed 11 Apr 2018 09:32:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30999 Wed 09 Feb 2022 15:59:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38419 Wed 08 Sep 2021 16:10:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40064 Wed 06 Mar 2024 15:05:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50685 Wed 01 May 2024 15:09:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47819 11.0 µmol/L (p = 0.012), cysteine levels were <255 µmol/L (p = 0.033) and serum folate was <22.0 nmol/L (p = 0.003; in males only). In females, dietary intake of total folate <336 µg/day (p=0.001), natural folate <270 µg/day (p = 0.011), and vitamin B2 < 1.12 mg/day (p = 0.028) was associated with an increased AD risk. These results support Hcy, Cys, and SF as useful biomarkers for AD, irrespective of APOE4 genotype and as such should be considered as part of screening and managing risk of AD.]]> Wed 01 Feb 2023 09:58:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36292 Tue 28 Apr 2020 06:20:28 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39248 TCD , as an indicator of vascular stiffening and vascular health. We investigate the correlations of the new index and the existing indices, namely the pulsatility index and the augmentation index, with age, cardiorespiratory fitness (CRF) and magnetic resonance imaging (MRI) blood flow pulsatility index (PI_MRI). Notably, the new index showed stronger correlations with CRF (r = −0.79) and PI MRI (r = 0.53) compared with the augmentation index (r = −0.65 with CRF and no significant correlation with PI_MRI) and the pulsatility index (no significant correlations with CRF or PI_MRI), and a similar correlation with age as the augmentation index. The clearer relationship of the proposed timing index with vascular aging factors underlines its utility as an early indicator of vascular stiffening.]]> Tue 27 Feb 2024 13:54:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54436 Tue 27 Feb 2024 13:49:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35549 Inhba, Egfr, and Rgs2 transcripts were elevated in associated aneuploid vs euploid oocytes from both TgFSH and wildtype females. In vivo, embryos transferred from subfertile 6-month-old TgFSH females to wildtype recipients yielded normal implantation rates and more pups born compared with controls. Transfer of wildtype embryos rescued the fertility of 6-month-old TgFSH-recipient females, although pup birth weight was reduced in TgFSH vs wildtype recipients. Our current findings show that elevated FSH had minimal disruption of either embryo developmental capacity or uterine function when examined in isolation, and the subfertility of TgFSH female mice was not caused by altered oocyte aneuploidy or quality.]]> Tue 27 Aug 2019 12:35:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55705 Tue 18 Jun 2024 12:48:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52536 Tue 17 Oct 2023 10:05:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55157 Tue 16 Apr 2024 15:23:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46315 Tue 15 Nov 2022 11:31:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47039 Tue 13 Dec 2022 14:15:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44253 Tue 11 Oct 2022 12:28:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55572 Tue 11 Jun 2024 11:22:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52399 Tue 10 Oct 2023 18:07:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30655 Tue 03 Sep 2019 18:30:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34229 proportional reduction in CSA in young and aging mice. This produced the same pressure gradient across the constriction and the same rise in B-type natriuretic peptide expression. Young mice showed acute deterioration in systolic function assessed by pressure-volume loops, progressive LV remodeling on echocardiography, and a 50% mortality at 12 weeks post-TAC. In contrast, aging mice showed no acute deterioration in systolic function, much less ventricular remodeling and were protected from death. Aging mice also showed significantly increased levels of matrix metalloproteinase-3 (MMP-3; 3.2 fold increase, P<0.001) and MMP-12 (1.5-fold increase, P<0.001), which were not seen in young mice. Expression of tissue inhibitor of MMP-1 (TIMP-1) increased 8.6-fold in aging hearts vs 4.3-fold in young hearts (P<0.01). In conclusion, following size-appropriate TAC, aging mice exhibit less LV remodeling and lower mortality than young adult mice. This is associated with induction of protective ECM changes.]]> Tue 03 Sep 2019 18:22:57 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24681 Tue 01 May 2018 15:44:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35751 Thu 28 Nov 2019 12:38:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45401 Thu 27 Oct 2022 17:29:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32076 Thu 27 Jan 2022 15:57:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39702 Thu 22 Feb 2024 11:29:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32911 Thu 14 Apr 2022 11:01:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30931 41 completed weeks of gestation (late-term) would show changes consistent with aging that would also be present in placentas associated with stillbirths. Objective: We sought to determine whether placentas from late-term pregnancies and unexplained stillbirth show oxidative damage and other biochemical signs of aging. We also aimed to develop an in vitro term placental explant culture model to test the aging pathways. Study Design: We collected placentas from women at 37-39 weeks’ gestation (early-term and term), late-term, and with unexplained stillbirth. We used immunohistochemistry to compare the 3 groups for: DNA/RNA oxidation (8-hydroxy-deoxyguanosine), lysosomal distribution (lysosome-associated membrane protein 2), lipid oxidation (4-hydroxynonenal), and autophagosome size (microtubule-associated proteins 1A/1B light chain 3B, LC3B). The expression of aldehyde oxidase 1 was measured by real-time polymerase chain reaction. Using a placental explant culture model, we tested the hypothesis that aldehyde oxidase 1 mediates oxidative damage to lipids in the placenta. Results: Placentas from late-term pregnancies show increased aldehyde oxidase 1 expression, oxidation of DNA/RNA and lipid, perinuclear location of lysosomes, and larger autophagosomes compared to placentas from women delivered at 37-39 weeks. Stillbirth-associated placentas showed similar changes in oxidation of DNA/RNA and lipid, lysosomal location, and autophagosome size to placentas from late-term. Placental explants from term deliveries cultured in serum-free medium also showed evidence of oxidation of lipid, perinuclear lysosomes, and larger autophagosomes, changes that were blocked by the G-protein-coupled estrogen receptor 1 agonist G1, while the oxidation of lipid was blocked by the aldehyde oxidase 1 inhibitor raloxifene. Conclusion: Our data are consistent with a role for aldehyde oxidase 1 and G-protein-coupled estrogen receptor 1 in mediating aging of the placenta that may contribute to stillbirth. The placenta is a tractable model of aging in human tissue.]]> Thu 09 Dec 2021 11:03:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52201 Thu 05 Oct 2023 10:08:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13880 Sat 24 Mar 2018 08:25:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14580 Sat 24 Mar 2018 08:22:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19040 Sat 24 Mar 2018 08:05:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20730 Sat 24 Mar 2018 08:00:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17241 Sat 24 Mar 2018 07:59:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19120 Sat 24 Mar 2018 07:55:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20695 Sat 24 Mar 2018 07:55:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18526 Sat 24 Mar 2018 07:50:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27863 Sat 24 Mar 2018 07:41:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26133 Sat 24 Mar 2018 07:41:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28830 Sat 24 Mar 2018 07:38:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29662 n = 18 886; ELSA, n = 9181; HRS, n = 19 303; and SHARE, n = 29 917. The microdata, along with further details about the harmonization process and all metadata, are available through the World Health Organization (WHO) data archive at [http://apps.who.int/healthinfo/systems/surveydata/index.php/catalog]. Further information and enquiries can be made to [sagesurvey@who.int] or the corresponding author. The data resource will continue to be updated with data across additional waves of these surveys and new waves.]]> Sat 24 Mar 2018 07:32:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28682 n = 10), PT (n = 8) and control (n = 9). OGT and OGA mRNA levels were measured from muscle samples obtained at baseline and after one year. Knee extensor muscle cross-sectional area (CSA), knee extension force, running speed and vertical jumping height were measured. During the yearlong intervention, HRT suppressed the aging-associated upregulation of OGT mRNA that occurred in the controls. The effects of PT were similar but weaker. HRT also tended to increase the OGA mRNA level compared to the controls. The change in the ratio of OGT to OGA gene expressions correlated negatively with the change in muscle CSA. Our results suggest that OGT and OGA gene expressions are associated with muscle size during the critical postmenopausal period. HRT and PT influence muscle OGT and OGA gene expression, which may be one of the mechanisms by which HRT and PT prevent aging-related loss of muscle mass.]]> Sat 24 Mar 2018 07:30:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29742 Sat 24 Mar 2018 07:27:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25132 Sat 24 Mar 2018 07:17:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22814 Sat 24 Mar 2018 07:15:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24915 Sat 24 Mar 2018 07:14:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24954 KO astrocytes did not augment transforming growth factor β after immune challenge and failed to resolve microglial activation. Collectively, a major cytokine-regulatory loop between activated microglia and astrocytes is impaired in the aged brain.]]> Sat 24 Mar 2018 07:14:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24080 Sat 24 Mar 2018 07:09:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55790 45 years) construction workers and nurses. The study period spanned 54 months, from January 2018 to June 2022, which equates to approximately 27 months before and 27 months after the World Health Organization declared COVID-19 a global pandemic on March 11, 2020. The tweets were analyzed using big data analytics and computational linguistic analyses. Results: Text analyses revealed that nurses made greater use of hashtags and keywords (both monograms and bigrams) associated with burnout, health issues, and mental health compared to construction workers. The COVID-19 pandemic had a pronounced effect on nurses’ tweets, and this was especially noticeable in younger nurses. Tweets about health and well-being contained more first-person singular pronouns and affect words, and health-related tweets contained more affect words. Sentiment analyses revealed that, overall, nurses had a higher proportion of positive sentiment in their tweets than construction workers. However, this changed markedly during the COVID-19 pandemic. Since early 2020, sentiment switched, and negative sentiment dominated the tweets of nurses. No such crossover was observed in the tweets of construction workers. Conclusions: The social media analysis revealed that younger nurses had language use patterns consistent with someone experiencing the ill effects of burnout and stress. Older construction workers had more negative sentiments than younger workers, who were more focused on communicating about social and recreational activities rather than work matters. More broadly, these findings demonstrate the utility of large data sets enabled by social media to understand the well-being of target populations, especially during times of rapid societal change.]]> Sat 22 Jun 2024 12:53:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38401 Mon 29 Jan 2024 17:48:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51984 Mon 25 Sep 2023 14:57:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54966 Mon 25 Mar 2024 12:11:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44817 Mon 24 Oct 2022 09:38:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44759 Mon 24 Oct 2022 08:49:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32907 Mon 23 Sep 2019 13:50:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31972 Mon 23 Sep 2019 11:05:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32295 Mon 21 May 2018 15:30:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53246 Mon 20 Nov 2023 10:14:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46268 Mon 14 Nov 2022 15:06:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43042 0.05). A significant reduction in 10SST peak power was found in both masters (P = 0.002) and young (P = 0.003) cyclists at 1 h post exercise, however, both groups physically recovered at similar rates. Neither group showed significant (P > 0.05) or practically meaningful increases in CK (%∆ < 10%). A significant age-related difference was found for perceptual fatigue (P = 0.01) and analysis of effect size (ES) showed that perceptual recovery was delayed with masters cyclists reporting lower motivation (ES ±90%CI = 0.69 ± 0.77, moderate), greater fatigue (ES = 0.75 ± 0.93, moderate) and muscle soreness (ES = 0.61 ± 0.70, moderate) after 48 h of recovery. Conclusion: The delay in perceived recovery may have negative effects on long-term participation to systematic training.]]> Mon 12 Sep 2022 12:31:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40983 Mon 08 Aug 2022 14:27:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40279 Mon 08 Aug 2022 11:55:28 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51415 Mon 04 Sep 2023 14:57:48 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55458 Mon 03 Jun 2024 08:51:54 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34596 Mon 01 Apr 2019 13:59:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43798 1 site), and one third had ≥5 joint pain sites. Compared to women with fewer joint pain sites, women with >5 joint pain sites (multisite joint pain) had significantly poorer physical and emotional health-related quality of life, more severe pain, a higher probability of neuropathic pain, and a longer duration of pain. More than half of women in the multisite joint pain group were still employed, statistically significantly more than women with no joint pain. In the final model, pain duration, the number of medications, pain intensity (discomforting and distressing) and the physical component of health-related quality of life were significantly associated with increased number of joint pain sites. Conclusions: Over one-third of older women in our sample had >5 painful joints in the last month. These women demonstrated significantly poorer psychosocial health, and increased medication use, than women with no or fewer sites of joint pain. Many women with multisite joint pain were still in the workforce, even when nearing retirement age. This study has important implications for future research into musculoskeletal pain, particularly in regards to womens health and wellbeing, and for clinical practice where there should be increased awareness of the implications of concurrent, multisite joint pain.]]> Fri 30 Sep 2022 14:15:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50078 Fri 30 Jun 2023 15:18:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36538 Fri 29 May 2020 17:22:29 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48100 Fri 24 Feb 2023 15:31:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41076 Fri 22 Jul 2022 17:04:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40610 n = 1768), at year one (n = 1373) and a restricted cohort (with possible or definite cognitive impairment) at year two (n = 370) had medication regimens documented by a research nurse during a home visit. Anticholinergic medicines were categorized as levels 1-3 (low-high potency) and summed for each participant as a measure of their ACL. RESULTS: Most participants had no change in ACL over time, but there was some turnover in the anticholinergic medications used. The mean change in ACL was 0.012 ± 0.99 from baseline to 12 months and −0.04 ± 1.3 from baseline to 24 months. Cardiovascular drugs were the most commonly used level 1 anticholinergics, followed by antidepressants and opioids. Antidepressants and urologicals were the most commonly used level 3 anticholinergics. The rate of anticholinergic deprescribing was equivalent to the rate of anticholinergic initiation, and commonly involved the level 1 drugs warfarin, furosemide and temazepam, and the level 3 drugs amitriptyline and oxybutynin. People with dementia had a higher ACL at baseline and year one compared with other participants. CONCLUSION: ACL of community-dwelling older people was very stable over time. This may represent lost opportunities for deprescribing as well as potentially inappropriate prescribing, particularly in those with cognitive impairment.]]> Fri 15 Jul 2022 11:49:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40033 Fri 15 Jul 2022 10:11:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38215 50 years, n = 92). The latter were further subdivided into two subgroups with (CV+, n = 25) and without (CV−, n = 67) cardiovascular risk factors. Arterial pulsatility was measured using cardiac-gated phase-contrast flow quantification sequence and three indexes of whole-brain white matter microstructural organization [i.e., fractional anisotropy (FA), radial diffusivity (RaD), mean diffusivity (MD)] were derived from diffusion-weighted imaging (DWI). Cognitive ability was assessed using global cognitive functioning (MoCA) and a measure of working memory [sensitivity (d′) from a 2-back task]. Neither the whole group analysis nor the younger adult group showed an association between measures of arterial pulsatility, global white matter microstructural organization, and cognition. In older adults, higher MD and RaD were associated with increased arterial pulsatility and poorer working memory performance. The indirect pathway from arterial pulsatility to working memory performance via both MD and RaD measures was significant in this group. Interestingly, a comparison of CV+ and CV− subgroups showed that this mediating relationship was only evident in older adults with at least one CV risk factor. These findings are consistent with cardiovascular risk factors as underlying arterial, white matter, and cognitive decline in cognitively normal older adults.]]> Fri 13 Aug 2021 14:31:48 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55138 Fri 12 Apr 2024 14:17:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51559 Fri 08 Sep 2023 16:29:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53582 Fri 08 Dec 2023 15:47:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36210 Fri 06 Mar 2020 11:26:43 AEDT ]]>